Motor Neuron Disease (MND) is a disorder that involves the
upper and lower motor neurons. Patients usually present with
weakness in the extremities, often with pain. Hyperreflexia,
fasciculations and muscular atrophy may also be seen.
Sensation usually remains unaffected. Weakness progresses to
involve the rest of the body. Death usually occurs two to
three years after onset of symptoms (mostly due to respiratory
- There is a loss of the normal ventral bulge (flattened) of
the cervical spinal cord, more so to the right over the C5 to
C7 levels. Hyperintense signal, best appreciated on the GRASS
axial images is seen within the cervical spinal cord,
ventrally (anterior horn cells) over these levels.